Gget

This is a unified interface to 20+ bioinformatics databases that works both as a CLI and Python package. You can pull gene info from Ensembl, run BLAST searches, grab AlphaFold structures, and do enrichment analysis without memorizing different API formats for each database. The modules are tested biweekly since the underlying databases change their schemas regularly, which matters if you're automating anything. It's genuinely useful for quick interactive lookups and exploratory work, but if you're doing heavy batch processing or need more complex BLAST configurations, you'll still want biopython. The consistent interface across modules is the real win here. Install it in a clean virtual environment because bioinformatics dependencies clash constantly.