Gene Database

Wraps both NCBI's E-utilities and the newer Datasets API so you can query gene data without wrestling with XML responses or rate limits yourself. You get scripts for searching by symbol or ID, fetching RefSeqs and GO annotations, and batch processing gene lists with automatic throttling. The dual API approach is actually useful since E-utilities handles complex cross-database queries while Datasets is faster for straightforward lookups. Ships with solid documentation on query patterns and works across species, though you'll want to always specify organism when searching by symbol to avoid matching the wrong gene. Good for annotation pipelines or anything that needs reliable access to NCBI Gene without building the plumbing yourself.