Clinpgx Database

This connects you to the ClinPGx API, the successor to PharmGKB that consolidates pharmacogenomics data for clinical decision support. Query gene-drug interactions (like CYP2D6 and codeine), pull CPIC guidelines with phenotype-specific dosing recommendations, and look up allele functions across populations. The API is straightforward REST calls with no auth required, though watch the 2 requests per second rate limit. Most valuable when you're building precision medicine tools or need to programmatically check if a patient's genotype affects drug metabolism, efficacy, or toxicity risk. Covers the major pharmacogenes (CYP450s, TPMT, DPYD, HLA variants) and includes evidence levels so you know what's guideline-backed versus preliminary.