If you're doing microbiome or phylogenetic analysis in Python, this skill gives Claude hands-on access to scikit-bio's core toolkit. It handles the usual sequence operations (DNA/RNA/protein manipulation, FASTA/FASTQ I/O, alignments), but the real strength is in microbial ecology workflows: calculating alpha and beta diversity metrics, UniFrac distances, building phylogenetic trees from distance matrices, and running ordination analyses like PCoA. The pair_align engine replaced the old alignment methods in 0.7.0, so you get modern global/local alignment with configurable gap penalties in one function. Good fit when you need to move beyond basic sequence work into community ecology statistics or when you're already knee-deep in microbiome data and need to calculate diversity metrics or run PERMANOVA tests.
npx skills add https://github.com/k-dense-ai/scientific-agent-skills --skill scikit-bio