Integrates five major pathway databases (Reactome, KEGG, WikiPathways, BioCarta, NCI-PID) for systems biology analysis. Run pathway enrichment on gene lists from RNA-seq or proteomics, map proteins to their biological pathways across multiple sources, or search by keyword to find relevant pathways and computational models. The skill emphasizes compute over description, pushing you to run actual Python enrichment statistics rather than theorizing. One smart touch is the built-in skepticism about enrichment versus causation, reminding you that three genes hitting a 200-member pathway means less than fifteen genes in a 40-member one. Cross-database validation is baked in since pathway annotations frequently disagree between sources.
npx skills add https://github.com/mims-harvard/tooluniverse --skill tooluniverse-systems-biology