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Appendix

appendixhealth/mcp-server
HTTPregistry active
Summary

Connects Claude to Appendix's physician review service for medical consultations. Exposes three tools: search_knowledge_base for querying medical literature and treatment guidelines, submit_encounter for sending clinical summaries to board-certified doctors for review and prescriptions, and list_conditions for browsing available conditions and medications. You'd use this when building AI health tools that need actual physician oversight rather than just LLM-generated medical advice. The server runs over streamable HTTP at mcp.appendix.com/mcp and works with Claude Desktop, Claude Code, and the Anthropic Messages API. Think of it as turning any AI health conversation into a doctor-reviewed clinical encounter with real prescription authority when needed.

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Appendix MCP Server

Appendix turns any AI health conversation into a physician-reviewed opinion, with a prescription if you need one.

Your agent writes a medical encounter summary, submits it through our API, and a real doctor signs off.

Use the Appendix MCP server to search medical literature, submit clinical encounters, and receive clinical guidance and prescriptions from board-certified physicians. Learn more at appendix.com.

Installation

Claude Code

claude mcp add --transport http appendix https://mcp.appendix.com/mcp

Claude Desktop / Claude Web Connectors

Add to your Claude Desktop config (claude_desktop_config.json) or Claude.ai custom-connector form:

{
  "mcpServers": {
    "appendix": {
      "url": "https://mcp.appendix.com/mcp"
    }
  }
}

Other clients

ClientURL
Claude Code, Claude Desktop, Claude.ai connectorshttps://mcp.appendix.com/mcp
Anthropic Messages API (mcp_servers)https://mcp.appendix.com/mcp

The server speaks Streamable HTTP only — the current MCP spec transport (2025-03-26).

Available Tools

ToolDescription
search_knowledge_baseSearch medical literature and treatment guidelines
submit_encounterSubmit a clinical letter for physician review
list_conditionsList available conditions and medications

Development

npm install
npm run build
npm start

Watch mode:

npm run dev

Environment Variables

VariableDefaultDescription
API_BASE_URLhttps://api.appendix.comAppendix API base URL
PORT3001HTTP listener port

Endpoints

MethodPathPurpose
GET/healthRender health probe
POST GET DELETE/mcpStreamable HTTP transport (stateless mode)
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Registryactive
TransportHTTP
UpdatedJun 2, 2026
View on GitHub