Connects Claude to your Obsidian vault through local semantic search powered by embeddings and "catalysts," which are pre-computed questions that surface cross-document patterns beyond basic keyword matching. After installing the CLI and running `enzyme init`, you get search and retrieval tools that work with your existing markdown structure: tags, wikilinks, frontmatter, daily notes, folder conventions. The index stays local in SQLite. Excerpts hit an LLM during setup to generate catalysts, but you can point it at your own OpenAI-compatible endpoint or local model. Reach for this when you want an agent to pull relevant context from accumulated notes without manually tagging everything or when keyword search misses conceptual connections spread across your vault.