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Complex Portal

pipeworx-io/mcp-complex-portal
HTTPregistry active
Summary

Connects to the EBI Complex Portal, which catalogs macromolecular complexes and their biological annotations. Part of the Pipeworx gateway ecosystem that routes requests across hundreds of biological data sources. The docs don't list specific tools, but you can query it using ask_pipeworx with natural language questions about protein complexes, and the gateway handles the routing. Useful when you need programmatic access to curated complex data without dealing with REST APIs directly. Ships as a streamable HTTP endpoint, so no local installation needed. If you're already using Pipeworx for other life science data, this slots right into that workflow.

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mcp-complex-portal

EBI Complex Portal MCP.

Part of Pipeworx — an MCP gateway connecting AI agents to 1476+ live data sources.

Tools

ToolDescription
search_complexesSearch the EBI Complex Portal — a manually curated database of stable macromolecular protein complexes — by protein/complex name, gene, GO term, or biological process (e.g. "apoptosis", "SCF", "ribosome"). Returns matching complexes with their accession (e.g. CPX-7762), name, description, and organism. Keyless. Complements UniProt/IntAct/STRING.
get_complexGet a single Complex Portal record by its accession (e.g. CPX-7762). Returns the complex's participants (subunits) with UniProt identifiers, biological roles and stoichiometry, plus systematic name, function, species, and description. Keyless. Complements UniProt/IntAct/STRING.

Quick Start

Add to your MCP client (Claude Desktop, Cursor, Windsurf, etc.):

{
  "mcpServers": {
    "complex-portal": {
      "url": "https://gateway.pipeworx.io/complex-portal/mcp"
    }
  }
}

What this endpoint actually serves

tools/list at https://gateway.pipeworx.io/complex-portal/mcp returns the tools in the table above plus the shared Pipeworx meta-tools — ask_pipeworx, discover_tools, search_within, remember/recall and the rest of the gateway-wide set. So the tool count you see is larger than this table: a single-pack endpoint currently lists roughly 30 shared tools alongside the pack's own. The connection's initialize response states its exact scope, and is the authoritative answer for a given day.

This is deliberate, not multiplexing by accident. The meta-tools are what let a scoped connection answer a question this pack does not cover — via ask_pipeworx, which routes across the whole catalog — without you adding a second MCP server. There is currently no way to mount a pack endpoint without them; if the extra schemas cost you more context than the routing is worth, connect to the full gateway once rather than to several pack endpoints.

Or connect to the full Pipeworx gateway to get every pack's tools listed directly, instead of just this one's:

{
  "mcpServers": {
    "pipeworx": {
      "url": "https://gateway.pipeworx.io/mcp"
    }
  }
}

Both URLs reach the same gateway and the same 1476+ data sources. The only difference is which pack's tools are listed directly; ask_pipeworx reaches all of them from either one.

Using with ask_pipeworx

Instead of calling tools directly, you can ask questions in plain English — this works on the pack endpoint above as well as on the full gateway:

ask_pipeworx({ question: "your question about Complex Portal data" })

The gateway picks the right tool and fills the arguments automatically.

More

  • Docs and guides
  • pipeworx.io

License

MIT

No MCP client? Call it over HTTP

curl -X POST https://gateway.pipeworx.io/v1/tools/search_complexes \
  -H 'Content-Type: application/json' \
  -d '{"query":"ribosome"}'

No account needed for the first calls. Inspect any tool: GET https://gateway.pipeworx.io/v1/tools/search_complexes. Find one: POST https://gateway.pipeworx.io/v1/tools/search_packs with {"query":"..."}.

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Registryactive
TransportHTTP
UpdatedJun 9, 2026
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