Summary
Connects Claude to the IUPHAR/BPS Guide to Pharmacology database without requiring API keys. Runs through Pipeworx's gateway, which handles authentication and routing for you. The source doesn't list specific tools, but GtoPdb typically covers ligand interactions, receptor data, and drug target information across pharmacological research. You'd use this when working with pharmaceutical data, researching drug mechanisms, or querying receptor classifications without managing your own API credentials. Part of Pipeworx's larger collection of 823+ data sources, so you can either use this standalone endpoint or connect to their full gateway for broader access.
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mcp-guidetopharmacology
IUPHAR/BPS Guide to PHARMACOLOGY (GtoPdb) MCP — keyless.
Part of Pipeworx — an MCP gateway connecting AI agents to 1476+ live data sources.
Tools
| Tool | Description |
|---|---|
search_ligands | Search the Guide to PHARMACOLOGY (IUPHAR/BPS) — an expert-curated pharmacology database — for drug ligands by name. Returns matching ligands with their GtoPdb ligand id, type (e.g. Synthetic organic, Peptide, Antibody, Metabolite), and approval status. Use the returned ligand id with ligand_interactions to find which protein targets it acts on. Keyless. Complements ChEMBL/DrugBank. |
search_targets | Search the Guide to PHARMACOLOGY (IUPHAR/BPS) — an expert-curated pharmacology database — for protein targets by name. Returns matching targets with their GtoPdb target id, abbreviation, and type (e.g. GPCR, CatalyticReceptor, Enzyme, Transporter). Use the returned target id with target_interactions to find ligands that bind it. Keyless. Complements ChEMBL/DrugBank. |
target_interactions | List the quantitative ligand interactions for a protein target in the Guide to PHARMACOLOGY (IUPHAR/BPS). Given a GtoPdb target id (from search_targets), returns the ligands acting on it with interaction type (Agonist/Antagonist/Inhibitor/etc.), action, and binding affinity (e.g. pKi/pIC50). Keyless. |
ligand_interactions | What proteins a drug acts on — the curated target interactions for a ligand in the Guide to PHARMACOLOGY (IUPHAR/BPS), each with the target PROTEIN NAME, interaction type (Agonist/Antagonist/Inhibitor), action and binding affinity (pKi/pIC50). Pass the drug by name ("imatinib") and it is resolved for you; a GtoPdb ligand id also works. The response always names the ligand it actually read, so an id that turns out to be a different compound is visible rather than silent. Keyless. |
Quick Start
Add to your MCP client (Claude Desktop, Cursor, Windsurf, etc.):
{
"mcpServers": {
"guidetopharmacology": {
"url": "https://gateway.pipeworx.io/guidetopharmacology/mcp"
}
}
}
What this endpoint actually serves
tools/list at https://gateway.pipeworx.io/guidetopharmacology/mcp returns the tools in the table
above plus the shared Pipeworx meta-tools — ask_pipeworx,
discover_tools, search_within, remember/recall and the rest of the
gateway-wide set. So the tool count you see is larger than this table: a
single-pack endpoint currently lists roughly 30 shared tools alongside the
pack's own. The connection's initialize response states its exact scope, and
is the authoritative answer for a given day.
This is deliberate, not multiplexing by accident. The meta-tools are what let a
scoped connection answer a question this pack does not cover — via
ask_pipeworx, which routes across the whole catalog — without you adding a
second MCP server. There is currently no way to mount a pack endpoint without
them; if the extra schemas cost you more context than the routing is worth,
connect to the full gateway once rather than to several pack endpoints.
Or connect to the full Pipeworx gateway to get every pack's tools listed directly, instead of just this one's:
{
"mcpServers": {
"pipeworx": {
"url": "https://gateway.pipeworx.io/mcp"
}
}
}
Both URLs reach the same gateway and the same 1476+ data sources. The
only difference is which pack's tools are listed directly; ask_pipeworx
reaches all of them from either one.
Using with ask_pipeworx
Instead of calling tools directly, you can ask questions in plain English — this works on the pack endpoint above as well as on the full gateway:
ask_pipeworx({ question: "your question about Guidetopharmacology data" })
The gateway picks the right tool and fills the arguments automatically.
More
License
MIT
No MCP client? Call it over HTTP
curl -X POST https://gateway.pipeworx.io/v1/tools/search_ligands \
-H 'Content-Type: application/json' \
-d '{"name":"aspirin"}'
No account needed for the first calls. Inspect any tool: GET https://gateway.pipeworx.io/v1/tools/search_ligands. Find one: POST https://gateway.pipeworx.io/v1/tools/search_packs with {"query":"..."}.
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Fastest browser for AI agents to run web automation tasks, always free.
Download Free life-time →Integrate web data into your AI product. One API to scrape website & brand data.
Get API Key Now →belt cli automatically finds the best tools and skills for your agent. image, video, music, tts...
one prompt install →Connect your Claude agent to live crypto prices and trading routes via 1inch
Get the MCP →