TRIALPATH

Mirrors the entire ClinicalTrials.gov database and exposes it through 9 MCP tools: search trials, get AI-generated plain-language briefs, replay historical snapshots, query field-level changes, match patients to eligible studies across any condition, look up sponsor and investigator activity, pull a catalyst calendar of upcoming milestones, and subscribe to changes via webhook or SSE. Originally built for Parkinson's research but covers every condition and sponsor in the registry. Runs on a pay-per-call model settled in USDC on Base via the x402 protocol, with most calls costing $0.005 to $0.02. Free tier gives you 25 calls per 24 hours with an API key. Reach for this when you need programmatic access to clinical trial data without scraping XML feeds or hitting rate limits on the public API.