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Independent project, not affiliated with Anthropic
mims-harvard avatar

Tooluniverse Crispr Screen Analysis

mims-harvard/tooluniverse
344 installs1.6k stars
Summary

This handles the full CRISPR screen analysis pipeline, from sgRNA count matrices through gene-level scoring to pathway enrichment and drug target prioritization. It implements MAGeCK-like ranking and BAGEL-like Bayes Factor approaches, runs quality control on library distributions, and integrates with DepMap to filter out pan-essential housekeeping genes from your context-specific hits. The workflow is practical: it checks for pre-computed results first (executed notebooks, existing analysis scripts) before re-running from raw data, which matters because reanalysis can take 5-10x more turns. Built around ToolUniverse tools like Enrichr, DGIdb, and PubMed for hit validation. Most useful for essentiality screens, synthetic lethality discovery, and resistance mechanism studies where you need statistical rigor and biological context together.

Install to Claude Code

npx -y skills add mims-harvard/tooluniverse --skill tooluniverse-crispr-screen-analysis --agent claude-code

Installs into .claude/skills of the current project.

CodeRabbit
CodeRabbit
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inference shell
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create and run specialised agents in minutes
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MCP-ready Email SendingMCP-ready Email Sending
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Plug Mailtrap into your AI workflow and let it handle the email.
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Make your agent a DeFi expert
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Agent, run crypto. Access onchain data & trade routes via 1inch.
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Capacitor - Shared memory for your team’s coding agents.
Capacitor - Shared memory for your team’s coding agents.
Make coding agent sessions - Searchable, Shareable, Vendor-neutral & Scored.
Try For Free →
CodeScene MCP ServerCodeScene MCP Server
CodeScene MCP Server
Your agent targets a perfect 10 Code Health score. Deterministic. Every commit.
Try For Free →
Give your AI the whole web as clean markdownGive your AI the whole web as clean markdown
Give your AI the whole web as clean markdown
Integrate web data into your AI product. One API to scrape website & brand data.
Get API Key Now →
belt - the only tool your agent needs
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belt cli automatically finds the best tools and skills for your agent. image, video, music, tts...
one prompt install →
CodeRabbit
CodeRabbit
AI writes the code. CodeRabbit catches the slop.
Try For Free →
inference shell
inference shell
create and run specialised agents in minutes
build now →
MCP-ready Email SendingMCP-ready Email Sending
MCP-ready Email Sending
Plug Mailtrap into your AI workflow and let it handle the email.
Connect Mailtrap MCP →
Make your agent a DeFi expert
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Agent, run crypto. Access onchain data & trade routes via 1inch.
Install now →
Capacitor - Shared memory for your team’s coding agents.
Capacitor - Shared memory for your team’s coding agents.
Make coding agent sessions - Searchable, Shareable, Vendor-neutral & Scored.
Try For Free →
CodeScene MCP ServerCodeScene MCP Server
CodeScene MCP Server
Your agent targets a perfect 10 Code Health score. Deterministic. Every commit.
Try For Free →
Give your AI the whole web as clean markdownGive your AI the whole web as clean markdown
Give your AI the whole web as clean markdown
Integrate web data into your AI product. One API to scrape website & brand data.
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belt - the only tool your agent needs
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belt cli automatically finds the best tools and skills for your agent. image, video, music, tts...
one prompt install →
Files
SKILL.md

Select a file.

Featured
CodeRabbit
CodeRabbit
AI writes the code. CodeRabbit catches the slop.
Try For Free →
inference shell
inference shell
create and run specialised agents in minutes
build now →
MCP-ready Email SendingMCP-ready Email Sending
MCP-ready Email Sending
Plug Mailtrap into your AI workflow and let it handle the email.
Connect Mailtrap MCP →
Make your agent a DeFi expert
Make your agent a DeFi expert
Agent, run crypto. Access onchain data & trade routes via 1inch.
Install now →
Capacitor - Shared memory for your team’s coding agents.
Capacitor - Shared memory for your team’s coding agents.
Make coding agent sessions - Searchable, Shareable, Vendor-neutral & Scored.
Try For Free →
CodeScene MCP ServerCodeScene MCP Server
CodeScene MCP Server
Your agent targets a perfect 10 Code Health score. Deterministic. Every commit.
Try For Free →
Give your AI the whole web as clean markdownGive your AI the whole web as clean markdown
Give your AI the whole web as clean markdown
Integrate web data into your AI product. One API to scrape website & brand data.
Get API Key Now →
belt - the only tool your agent needs
belt - the only tool your agent needs
belt cli automatically finds the best tools and skills for your agent. image, video, music, tts...
one prompt install →
Categories
Sales & MarketingCLI & Terminal
First SeenJun 3, 2026
View on GitHub

More from mims-harvard/tooluniverse

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  • Tooluniverse Gwas Trait To Gene333
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  • Devtu Self Evolve280
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  • Tooluniverse Sequence Retrieval1.6k
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Interpret a single GWAS SNP across multiple databases — GWAS Catalog hits, LD/haplotype context, eQTL evidence, regulatory annotation, ClinVar pathogenicity, gnomAD frequency. Use for 'what does this SNP do', SNP-to-mechanism tracing, and resolving lead-SNP-vs-causal-variant ambiguity. Always considers LD structure before claiming a SNP is mechanistically responsible.
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