Pdb Database

Gives you programmatic access to RCSB's 200,000+ experimentally determined protein and nucleic acid structures through their Python API. You can search by text, sequence similarity, or structural similarity, then pull down coordinate files in PDB or mmCIF format along with metadata like resolution and experimental methods. The querying is solid with support for complex logical operators and GraphQL for custom pulls. Most useful when you're doing computational structure work and need to batch download structures, compare binding pockets for drug discovery, or find homologs for protein modeling. The API wrapper is clean enough that you're not fighting with REST endpoints directly.