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Prioritize drug targets from a ranked gene list (e.g., scRNA-seq DE output) by orchestrating parallel API queries against UniProt, OpenTargets (with integrated DepMap CRISPR essentiality + gnomAD constraint), PubMed, the Human Protein Atlas (HPA), and ChEMBL tool compounds, then re-ranking by a composite score combining protein localization, druggability, disease genetics, tissue specificity (safety), focus-cell-type expression, CRISPR essentiality, LoF safety constraint, and research maturity. Use whenever the user wants to filter, triage, prioritize, or "do due diligence" on a list of candidate genes for drug discovery, especially after a DE / DEG analysis when they say things like "which of these should I follow up on", "filter for druggable targets", "make a target dossier", "rank these for tractability", "annotate these genes for druggability", or "build a target report". Trigger even when the user says just "filter these candidate genes" or hands over a CSV from a DE pipeline.

Run the daily wiki maintenance cycle: check all source freshness, update the index, and regenerate hot.md. Use this skill when the user says "/daily-update", "run the daily update", "update everything", "morning sync", "refresh the wiki index", or when triggered by the launchd cron at 9 AM. Also use to set up or verify the cron + terminal notification infrastructure for the first time ("set up the daily cron", "install the terminal notification", "how do I get the morning reminder?").

Capture desktop, app windows, or pixel regions across OS platforms. Useful for marketing screenshots, design reviews, and bug reports.

Produce distinctive, non-generic UI and design applications well, working strategy-first. Identify the project (landing page, SaaS app, dashboard, ecommerce, presentation, docs, portfolio...) and its positioning and personality, commit to brand adjectives, translate into a typography and color system, then apply the craft layer (layout, components and states, motion, iconography, imagery, dark mode and theming, accessibility), avoiding the AI-slop / Claude-esque default. This is both a de-slop and an expert app-design skill. Use this whenever building or styling any web frontend, app, dashboard, landing page, deck, or artifact, or when the user says "make it not look like AI", "de-slopify", "deslop", "less generic", "give it character", "design a UI for X", "design an app", "update DESIGN.md", or complains the output looks like every other AI site. Trigger even when the user just says "build a UI for X" without naming an aesthetic, because the default without this skill is slop.

Pure text-to-image generation for all creative scenarios (no reference photo). Covers logo design, poster design, illustration, meme, game assets, social media content, 3D rendering, education, fashion, food, pet, wedding, holiday marketing, and artistic styles. Use when generating images from text descriptions without a reference photo (e.g. design a logo, create a poster, generate game art, make a meme, 3D render).

Full-lifecycle AI music album production — concept, lyric drafting, track sequencing, and export. Useful for indie album experiments and brand soundtracks.