Tooluniverse Protein Structure Retrieval

This is a comprehensive protein structure lookup tool that handles the messiness of retrieving and comparing structures from RCSB PDB, PDBe, and AlphaFold. It includes quality assessment logic that distinguishes between high-resolution experimental structures (X-ray under 2 Angstroms for drug design) and predicted AlphaFold models with confidence scores. The workflow handles disambiguation when you search by protein name, pulls metadata like resolution and R-factors, identifies bound ligands and binding sites, and ranks alternative structures. The domain reasoning is solid: it knows cryo-EM at 3-4 Angstroms is good for overall fold but not side chains, and that AlphaFold struggles with disordered regions. If you're doing structural biology work or computational drug discovery and need reliable structure retrieval with built-in quality checks, this handles the tedious parts well.